Like Gluckman Mayner's numerous other museum commissions, including the Dia Center for the Arts in New York and the Museo Picasso in Malaga, Spain, the Deutsche Guggenheim embodies a pure, minimalist aesthetic. Simple detailing, careful spatial proportioning, and a restrained palette of materials combine to create an environment of respectful sensitivity for the presentation of art. The extensive modern technical equipment is nearly invisible, and the furniture, also designed by Gluckman, is completely neutral.

The hallmark of this unique collaboration between Deutsche Bank and the Guggenheim is the commissioning of major new works by leading contemporary artists, including Jeff Koons, Nam June Paik, James Rosenquist, Rachel Whiteread, and Bill Viola; the resulting installations have their public premiere in the gallery.